Address:

    Office: Biotechnology & Genetic Engineering Discipline, Khulna University, Khulna, Bangladesh. Residence: House: 2/8, Road: 18, Central North Block, Khalishpur, Khulna, Bangladesh.

    Email:

    shamim11_akhter@yahoo.com

    Contact:

    +8801718482468

    Personal Webpage:
    click here

Dr. Md. Shamim Akhter

Professor

Research Interest:

Molecular Medicine, Plant Biotechnology, Food Biotechnology


Education

University Education

Completion

Level

Schooling

Field

Result

University

 2015

PhD

3 years

Molecular Medicine

Cum Laude (Distinction)

University of Santiago de Compostela,  Spain

2003

MS

1.5 years

Biotechnology and Genetic Engineering

1st Class(Merit position: 1st)

Khulna University, Bangladesh

2001

B. Sc.

4 years

Biotechnology

1st Class (Merit position: 2nd)

Khulna University, Bangladesh

 

Field and achievements of PhD research:

Broad Field

Molecular Medicine
Specific Field

.Isolation and characterization of VGF derived neuropeptide receptor

Achievements

Using affinity chromatography and mass spectrometry-based protein identification, the heat shock cognate 71 kDa protein A8 (HSPA8) has been identified as a binding partner of human TLQP-21 on the surface of human neuroblastomaSH-SY5Y cells. Binding of TLQP-21 to membrane associated HSPA8 in live SH-SY5Y cells was further supported by cross-linking to live cells. Interaction between HSPA8 and TLQP-21 was confirmed in vitro by label-free Dynamic Mass Redistribution (DMR) studies. Furthermore, molecular modeling studies showed that TLQP-21 can be docked into the HSPA8 peptide binding pocket. Identification of HSPA8 as a cell surface binding partner of TLQP-21 opens new avenues to explore the molecular mechanisms of its physiological actions, and of pharmacological modulation thereof.

Pre-University Education

Completion

Level

Schooling

Field

Result

Institute

1995

HSC

2 years

Science

1st Division

Govt. B L University College, Khulna, Bangladesh

1993

SSC

10 years

Science

1st Division

Crescent High School, Khulna, Bangladesh

Bio

Experiences

Experience in Teaching

Serving as teaching & research faculty, at present, as professor, in Biotechnology and Genetic Engineering Discipline, Khulna University, Bangladesh since 2008. Before that, also served as lecturer in Department of Microbiology and Biotechnology, Gono University, Dhaka since 2004. 

Experience in Research

Skilled in basic and applied Molecular Biotechnology including immunohistochemical techniques, affinity chromatography, cell culture, cross-linking, FACS studies, 1 D & 2 D electrophoresis, etc.  Working experiences at different laboratories in Biotechnology and Genetic Engineering Discipline, Khulna University since 2008. Before that worked at Microbiology, Pharmaceutical and  Vaccine Lab of Gono University, Dhaka.



Publication

Akhter S, Chakraborty S, Moutinho D, AÂ lvarez-Coiradas E, Rosa I, Viñuela J, et al. (2017) The human VGF-derived bioactive peptide TLQP-21 binds heat shock 71 kDa protein 8 (HSPA8) on the surface of SH-SY5Y cells. PLoS ONE 12(9):e0185176. https://doi.org/10.1371/journal.pone.0185176

Chakraborty, S., Akhter, S., Requena, J. R., Basu, S. (2015) Probing the conformational dynamics of the bioactive peptide TLQP 21 in solution: A molecular dynamics study. Chemistry of biology and drug design. 86: 938–944, doi:10.1111/cbdd.12541.

Shamim  Akhter, Jesus Rodriguez Requena (2017) Oxymatrine (an inhibitor of HSPA8) reduces binding of VGF derived bioactive peptide TLQP-21 to the surface of live SH-SY5Y cells. Khulna University Studies. 14 (1 & 2): 71-82.

Sheikh Ashikur Rahman, Md. Shamim Akhter (2018) Antibacterial and cytotoxic activities of Carica papaya L. (Papaya) seeds. Khulna University Studies. 15 (1): 371-48.

Md. Shamim Akhter, Iffat Jerin (2017) Pathways involved in TLQP-21 mediated biological functions: A review. Journal of Business, Society and Science.  5: 16-32.

Md Shamim Akhter (2017) VGF: A brief introduction to it's structure, tissue distribution and functions. Bangladesh Journal of Progressive Science & Technology  (BJPST).  15(2): 001-008.

Akhter, S. (2017).  A study on the effect of VGF derived bioactive peptide TLQP-21 on ERK/AKT signalling in SH-SY5Y cells. International Conference on Bioinformatics and Biostatistics for Agriculture, Health and Environment of Department of Statistics, University of Rajshahi, Bangladesh and Bangladesh Bioinformatics and Computational Biology Association (BBCBA), 529-533.

M. S. Akhter, J. R. Requena (2017) Direct binding of TLQP-21 with HSPA8 protein: demonstrated by avidin agarose affinity chromatography. 5th International Conference on Chemical Engineering, ICChE 2017, Bioengineering organized by the Department of Chemical Engineering at Bangladesh University of Engineering and Technology (BUET), 103-113.

Md. Shamim Akhter, Jesús R. Requena.  Expression patterns of the phosphoproteins and total proteins in TLQP-21 (a VGF derived peptide) treated SH-SY5Y cells.  Journal of  Advanced  Biotechnology and  Experimental Therapeutics. 2018; 1(2):43-48.

Md. Shamim Akhter, Jojon Arif. (2018). The pathways involved in TLQP-62 mediated biological functions: A review.  Journal of Advances in Biotechnology. 7(1): 953-966.

Sheikh Ashikur Rahman, Md. Shamim Akhter. (2018).  Antibacterial and cytotoxic activity of seeds of white hyacinth bean (Lablab purpureus L. sweet ‘white’). Journal of  Advanced  Biotechnology and  Experimental Therapeutics. 2018; 1(2):49-54.

Md. Sahabuddin, Hafij Ali, Md. Faruque Miah, Enaya Zannath, M. S. Akhter, M. Billah, Z. Hassan and L. Ali (2015) Association of vitamin D receptor gene Apa1 (G>T) and Taq1(T>C) polymorphisms in the pathogenesis of impaired glucose tolerance in subjects of Bangladeshi origin. International Journal of Green and Herbal Chemistry (IJGHC), 4 (3): 357-369.

Md. Robiul Islam, S.M. Mahbubur Rahman, and Md. Shamim Akhter (2019) Effect of F. Oxysporum Extract on Seed Germination and Vegetative Growth of Abelmoschus esculentus (Okra). Bangladesh Army University of Engineering & Technology (BAUET) Journal. 2 (1): 13-20.

Fatema Tuj Johora Neela,Md. Masuder Rahman, Md. Shamim Akhter (2019) Physico-Chemical Characterization and Product Development from 5 Cultivars of Phoenix dactylifera l. (Date). European Journal of Scientific Exploration, 2(1): 1-10.

Mrinmoy Kumar Mondal,  Md. Shamim Akhter (2019) Anti-oxidant Activity of the Terminalia chebula Fruit Extracts in-vitro. International Conference on Engineering Research and Education, School of Applied sciences & Technology, Shahjalal University of Science and Technology, Sylhet. 709-714.

Mrinmoy Kumar Mondal,  Md. Shamim Akhter (2019) Phytochemical Screening of the Fruit of Terminalia chebula    (Family: Combretaceae).5th  International Conference on Engineering Research and Education, School of Applied sciences & Technology, Shahjalal University of Science and Technology, Sylhet. 715-720.

M K Islam, A Siddhika, D Manisha, S Akhter, Z Hassan, L Ali (2014). Association of vitamin D receptor gene Bsm1 (A>G) and Fok1 (C>T) polymorphism in the pathogenesis of impaired glucose tolerance in Bangladeshi subjects. SMU Medical Journal, 1(1): 67-78.

Md. Jalal Uddin, Md. Shamim Akhter, Kazi Mohammed Didarul Islam, and Md. Morsaline Billah (2014) Study on Cytotoxic Activity of Clerodendrum inerme and Caesalpinia crista by Brine Shrimp Lethality Bioassay. International Journal of Innovation and Applied Studies, 8(4):1574-1580.

Md. Shamim. Akhter. (2014). A study on pre-retting and post-retting water of waterbodies from a selected area (Satkhira, Khulna) of Bangladesh . Journal of Advances in Agriculture (JAA), 2(1) : 38-41.

K. M. Taufiqur Rahman, Md. Fahmid Islam, Rajat Suvra Banik, Ummay Honi, Farhana Sharmin Diba, Sharmin Sultana Sumi, Shah Md. Tamim Kabir, Md. Shamim Akhter. (2013). Changes in protein interaction networks between normal and cancer conditions: Total chaos or ordered disorder? Network Biology, 3(1): 15-28.

Md. Shamim Akhter, Md. Amir Hossain, Emran Hossain. (2013).  effect of various sustained release polymers on Naproxen Sodium Release from control release tablets. International Journal of Pharmacy Teaching & Practices (IJPTP), 4 (2) : 636 - 643.

M. S. Akhter, M. A. Mannan, A. A. Shoheli. (2013). Physico-chemical characterization and product development from local citrus germplasms available in the south western region of Bangladesh. Journal of Microbiology, Biotechnology and Food Sciences (JMBFS), 3(2) : 141-145.

Mrinmoy Kumar Mondol, Md. Iqbal Ahmed, Md. Shamim Akhter (2012). Antidiarrhoeal and analgesic activities of fruit of Terminalia chebula Linn. Jagannath University Journal of Science & Technology. 1( 1 ) : 75---81.

Md. Shamim Akhter, Dr. Md. Abdul Mannan and Runa La-ela (March, 2012). Physico-chemical characterization and product development from banana germplasms available in south western region of Bangladesh. International Research Journal of Applied Life Science.1(1) : 1---18.

 N. Sultana, T.A. Jahan, T.K. Barai, M.S. Akhter And N. Ara (2012). Tissue culture propagation of tropical orchid (Phaius tankervilliae). Plant Journal of Innovation & Development Strategy (JIDS). J. Innov. Dev. Strategy 6(1):81-85.

Md. Shamim Akhter, Dr. Md. Abdul Mannan and Sudipta Ghosh (2012). Physico-chemical characterization and product development from  papaya ( Carica papaya) germplasms available in south western region of Bangladesh. International Research Journal of Applied Life Science. 1(2) : 49---62.

Md.  Shamim   A k h t e r,  M. A .K. A z a d,  M.  Z..  R a h m a n  a n d   A  A s h r a f. (2013).   S t u d y  o n  t h e  q u a l I t y  o f  s e m e n   o f   d i f f e r e n t   g e n e t i c  groups  o f  b u l l  from Khulna region of Bangladesh.  International Journal of Pharmaceutical and Medical Research(IJPMR), 1(1) : 19-23.

 M.N. Hasan,  N. Sultana, M. S. Akhter, M.M. Billah And K. K. Islam.  (2012). Hypoglycemic effect of  methanolic extract from fruits of Sonneratia Caseolaris – a mangrove plant from Bagerhat region, The Sundarbans, Bangladesh. Plant Journal of Innovation & Development Strategy (JIDS). J. Innov. Dev. Strategy.

 Md. Shamim Akhter, Sheikh Julfikar Hossain, SK. Amir Hossain, Rakesh Kumar Datta. (2012). Isolation and characterization of salinity tolerant Azotobacter sp.  Greener Journal of Biological Sciences. 2 (3) : 043-051.

 Md. Shamim Akhter, Asif Ahamed ,M. Monzur Hossain. (2012) Agrobacterium mediated genetic transformation of eggplant (Solanum Melongena L.). International Journal of Pharmacy Teaching & Practices .3( 2) : 275-280.

 Md. Shamim Akhter, Dr. S.M. Mahbubur Rahman, Md. Hafizur Rahman. (2012).  Micropropagation of bauhinia acuminata L.  International Research Journal of Applied Life Science. 1(3) : 35---43.

Md. Shamim Akhter, Asif Ahamed ,M. Monzur Hossain. (2012) Agrobacterium mediated genetic transformation of eggplant (Solanum Melongena L.). International Journal of Pharmacy Teaching & Practices .3( 2) : 275-280.

 Md. Shamim Akhter, Sheikh Julfikar Hossain, SK. Amir Hossain, Rakesh Kumar Datta. (2012). Isolation and characterization of salinity tolerant Azotobacter sp.  Greener Journal of Biological Sciences. 2 (3) : 043-051.

 M.N. Hasan,  N. Sultana, M. S. Akhter, M.M. Billah And K. K. Islam.  (2012). Hypoglycemic effect of  methanolic extract from fruits of Sonneratia Caseolaris – a mangrove plant from Bagerhat region, The Sundarbans, Bangladesh. Plant Journal of Innovation & Development Strategy (JIDS). J. Innov. Dev. Strategy.

Md.  Shamim   A k h t e r,  M. A .K. A z a d,  M.  Z..  R a h m a n  a n d   A  A s h r a f. (2013).   S t u d y  o n  t h e  q u a l I t y  o f  s e m e n   o f   d i f f e r e n t   g e n e t i c  groups  o f  b u l l  from Khulna region of Bangladesh.  International Journal of Pharmaceutical and Medical Research(IJPMR), 1(1) : 19-23.

A  Naser, M H Rahman, P K Sarker and M S Akhter (2012) Isolation and characterization of protease enzyme  producing bacteria from soil samples of  a tannery area. South Asian Journal of Agriculture. 5 (1 & 2): 91-99.

M. S. Akhter, E. Hossain (December, 2008). Study of microbes in chemically polluted environment of a private sector health  care establishment. South Asian Journal of Agriculture, 3 (1 & 2):55-60.

T.K. Barai, M.S. Akhter, A Habib (December, 2009). Performance of oyster mushroom on different substrates. International Journal of Sustainable Agricultural Technology, 5(9) : 01-05.

M.S. Akhter, A Habib, T K Barai, June (2010).Quality assessment of a selected brand mango juice. Journal of Subtropical Agricultural Research & Development. 8(1 to 6): 841-845.

M.S. Akhter, A Ashraf, M M Rahman (December, 2008). Comparison of egg production of duck in different breeds & seasons. International Journal of Sustainable Agricultural Technology, 4(6):37-40.

M.S. Akhter, (October, 2008). Arsenic: it’s mobilization in ground water. International Journal of Sustainable Agricultural Technology, 4(5):29-34.

 

Book

Md. Shamim Akhter. 2012. Role of Proteomics in Pharmaceutical Science a Review. Lambert Academic Publishing, AV Akademikerverlag GmbH & Co., Germany. ISBN : 978-3-8465-9935-8.

Md. Shamim Akhter, Anupom Apora Shoheli, Dr. Md. Abdul Mannan. 2012. Characterization and Product Development from Local Citrus Germplasm a Study on 20 Selected Citrus Germplasm of South Western Region of Bangladesh. Lambert Academic Publishing, AV Akademikerverlag GmbH & Co., Germany. ISBN : 978-3-659-27884-6.

Md. Shamim Akhter, Rustom Ali. 2018. Antibacterial and Cytotoxic Activities of Carica papaya  Seed, Lambert Academic Publishing, International Book Market Service Ltd., OmniScriptum Publishing Group, Mauritius. ISBN: 978-613-9-94640-2.

Md. Shamim Akhter, Md Tasnimul Hasan. 2019. Cancer Origin and Progreassion: Enhancing the Understanding of Enigmas, Lambert Academic Publishing, International Book Market Service Ltd., OmniScriptum Publishing Group, Mauritius. ISBN: 978-613-9-99549-3.


 Poster:

Md. Shamim Akhter, Jesus Rodriguez Requena (2018) Binding of  TLQP-21 to the surface of  SH-SY5Y cells: Demonstration by fluorescence-activated cell sorting (FACS) analysis. 1st International Conference on Biological and Environmental Research: Recent Development, Challenges and Future Prospects (ICBER 2018), organized by Department of Environment and Technology, Jessore Science and Technology University, Bangladesh.

Sadia Hossain, Md. Hiron Khan, Nasrin Nahar Begum, Md Shamim Akhter  (2018) The physical, chemical, organoleptic and microbiological quality of meat and meat products: A case study in Gazipur District. 1st International Conference on Biological and Environmental Research: Recent Development, Challenges and Future Prospects (ICBER 2018), organized by Department of Environment and Technology, Jessore Science and Technology University, Bangladesh.

Mrinmoy Kumar Mondal and Md. Shamim Akhter (2018) Anti-oxidant activity of the Terminalia chebula fruit extracts in-vitro. International Conference on Chemical Science & Technology, organized by Department of Chemistry, Khulna University of Engineering & Technology (KUET), Khulna, Bangladesh.

Md. Shamim Akhter, Jesús R. Requena (2018) Oxymatrine (OMTR) inhibitor of HSPA8, reduces binding of TLQP-21 to SH-SySy cells: Immuno histochemical validation. International Conference on Chemical Science & Technology, organized by Department of Chemistry, Khulna University of Engineering & Technology (KUET), Khulna, Bangladesh.

Md. Shamim Akhter and Jesus Rodriguez Requena (2018) Binding of biotin-TlQP-21 to the surface of live SH-SY5Y cells: Demonstration by fluorescence-activated cell sorting (FACS) analysis. International Conference on Chemical Science & Technology, organized by Department of Chemistry, Khulna University of Engineering & Technology (KUET), Khulna, Bangladesh.

M. Shahabuddin, A. Siddika, M. Das, I. Khan, M. S. Akhter, M. Billah, Z. Hassan and L. Ali. Association of Vitamin D Receptor Gene G>T And T>C Polymorphisms in the Pathogenesis of Impaired Glucose Tolerance in a Subjects of Bangladeshi Origin. 1st international conference on Green Chemistry for  Sustainable Development ,  2012, Jessore Science and Technology University, Bangladesh.

Md. Shamim Akhter, Iffat Hossain. A Study on the Signaling pathways of VGF Derived peptide TLQP-2l.  Bangladesh Association of Biotechnology Graduates (BABG) 1st National Congress, 2017, Jahangirnagar University Dhaka, Bangladesh &  BABG.

Conference proceedings

Kanij Fatema, Md. Shamim Akhter (2019) Physico-Chemical Characterization and Product Development from Phyllanthus emblica  (Amlaki). Second national scientific conference on food safety and health, organized by Bangladesh Society for Safe Food (BSSF), pp 20.

Md. Shamim Akhter, Jesus Rodriguez Requena (2018) Molecular interaction analysis of HSPA8 and TLQP-21 by Surface Plasmon Resonance (SPR) Assay. 1st International Conference on Biological and Environmental Research: Recent Development, Challenges and Future Prospects (ICBER 2018), organized by Department of Environment and Technology, Jessore University of Science and Technology, Bangladesh, .

M. S. Akhter, M M Billah, K M D Islam, M J Uddin. Study on Bioactivity of Selected Shrubs of the  Sundarbans. 1st international conference on Green Chemistry for  Sustainable Development , July 2012, Jessore Science and Technology University, Bangladesh, 40.

M. Shahabuddin, A. Siddika, M. Das, I. Khan, M. S. Akhter, M. Billah, Z. Hassan and L. Ali. Association of Vitamin D Receptor Gene BSM1 (A>G) and Fok1 (C>T) Polymorphism  in    the Pathogenesis of Impaired Glucose Tolerance in a Bangladeshi Subjects. 1st international conference on Green Chemistry for  Sustainable Development , July 2012, Jessore University of Science and Technology, Bangladesh, 132-133.

M. K. Islam, A. Siddika, M. Das, I. Khan, M. S. Akhter, M. Billah, Z. Hassan and L. Ali. Association of Vitamin D Receptor Gene BSM1 (A>G) and Fok1 (C>T)  Polymorphism  in    the Pathogenesis of Impaired Glucose Tolerance in a Bangladeshi Subjects. 1st international conference on Green Chemistry for  Sustainable Development , July 2012, Jessore Science and Technology University, Bangladesh, 116-117.

Published Abstracts (Oral)

Md. Shamim Akhter and Jesus Rodriguez Requena (2018) 1st International Conference on Biological and Environmental Research: Recent Development, Challenges and Future Prospects (ICBER 2018), organized by Department of Environment and Technology, Jessore Science and Technology University, Bangladesh.

Molecular interaction analysis of HSpAS and TLQP-2l by Surface Plasmon Resonance (SPR) Assay

Md. Shamim Akhter, Jesús R. Requena (2018) Crosslinking and detection of TLQP-2l (a VGF derived peptide) binding protein in SH-SY5Y cell model. International Conference on Chemical Science & Technology, organized by Department of Chemistry, Khulna University of Engineering & Technology (KUET), Khulna, Bangladesh.

Mrinmoy Kumar Mondal, Rubel Howlader, Md. Shamim Akhter (2017). Bioactivity of Fruit of  Terminalia chebula Linn (Family- Combretaceae): Phytochemical and Pharmacological Screening. 5th AYUNS International Conference, Organized by: Ayurved & Naturopathy Association of Bangladesh. Journal of Ayurvedic and Traditional Medicines. 4 (1):  34-35.

Md. Shamim Akhter, Jojon Arif (2017) The pathways involved in TLQP-62 mediated biological functions: A review. 5th International Conference organized by Public Health Foundation of Bangladesh. Pp 89.

M. Shahabuddin, A. Siddka, M. Das, I Khan, M.S. Akhter,  M.Billah, Z. Hassan and L. Ali. Association of Vitamin D Receptor Gene G>T and T>C Polymorphisms in the pathogenesis of Impaired Glucose Tolerance in Subjects of Bangladeshi Origin’ international conference on green chemistry for sustainable   development. Jessore   Science & Technology  University, Jessore , Bangladesh, pp 132-133.


 Congress

1st Iberian Congress on Prions held in University of Santiago de Compostela, Spain from 3-4 December, 2012.

Bangladesh Association of Biotechnology Graduates (BABG) 1st National Congress  held in Jahangirnagar University, Dhaka on 28 April, 2017.


Conference

Terapia Celular e Medicina Rexenerativa (Cellular Therapy and Regenerative Medicine) organized by University of Coruna (UDC), Spain on 28 March, 2014.

Cancer : Research, Discovery, Therapeutics, Bioconference Live organized by LabRoots Inc, USA on 16-17 October, 2013, 2014.

Neuroscience, Bioconference Live organized by LabRoots Inc, USA on 19-20 March, 2014.

Clinical Diagnostics & Research, Bioconference Live organized by LabRoots Inc, USA on 28-30 May, 2014.

Laboratory Animal Sciences, Bioconference Live organized by LabRoots Inc, USA on 04-05 February, 2015.

Neuroscience, Bioconference Live organized by LabRoots Inc, USA on 18-19 March, 2015.

International Conference on Bioinformatics and Biostatistics for Agriculture, Health and Environment of Department of Statistics, 2017, University of Rajshahi, Bangladesh and Bangladesh Bioinformatics and Computational Biology Association (BBCBA).

International Conference on Chemical Engineering, ICChE 2017, Bioengineering organized by the Department of Chemical Engineering at Bangladesh University of Engineering and Technology (BUET), 103-113.

1st International Conference on Biological and Environmental Research: Recent Development, Challenges and Future Prospects, ICBER 2018, organized by Department of Environment and Technology, Jessore Science and Technology University, Bangladesh.

International Conference on Chemical Science & Technology, organized by Department of Chemistry, Khulna University of Engineering & Technology (KUET), Khulna, Bangladesh.

Seminar

Citogenetica para Clinica : Analisis con Arrays CGH de Oligos (Cytogenetics For Clinic : Analysis with Oligo Array CGH) organized by Agilent Technologies in University of Santiago de Compostela (USC), Spain on 10 April, 2014.

Purificacion de Proteinas (Purification of Proteins) organized by GE Healthcare Life Sciences in the Centre for Research in Molecular Medicine and Chronic Disease (CIMUS) of University of Santiago de Compostela (USC), Spain on 16 April, 2015.

Workshops/Trainings

Molecular Mechanisms of Neurodegeneration (webinar) organized by QIAGEN, Netherlands on 19 May, 2014.

Training workshop on ‘Biosafety and Biosecuirity in Laboratory Diagnosis and Research’ organized by Biotechnology and Genetic Engineering Discipline, Khulna University & International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) from 21-22 August, 2016.

Training on ‘Teaching & Learning of Faculty Members’ organized by Biotechnology and Genetic Engineering Discipline, Khulna University from 23-24 August, 2016.

Train the trainer on ‘The Essential of Electronic Agricultural Library’ organized by the Essential Electronic Agricultural Library (TEEAL)  from 20-21 April, 2016.

Training on ‘Teaching & Learning of Faculty Members’ organized by Biotechnology and Genetic Engineering Discipline, Khulna University from 23-24 November, 2016.

Evaluating and Selecting Chemistry Automation Solutions (webinar) organized by AACC, Netherlands on 29 September, 2017.