Address:

    Room #2423, Pharmacy Discipline, Academic Building #2, Khulna University, Sher-E-Bangla Road, Khulna-9208, Bangladesh

    Email:

    mmrahman0103@pharm.ku.ac.bd

    Contact:

    +880 1711 485602

    Personal Webpage:
    click here

Dr. Md. Mustafizur Rahman
Professor

Md. Mustafizur Rahman is a Professor of Pharmacy Discipline of Life Science School at Khulna University where he has been working as a faculty member since 2000. He served the Discipline as the Head of Pharmacy Discipline from March 23 2015 to March 22 2018. He received his B. Pharm. (Hon’s) & M. Pharm. degrees in Pharmacy from the University of Dhaka, Bangladesh. Right after completion of his study he started his career as Product Executive in a renowned Pharmaceutical Industry in Bangladesh. After acquiring professional experience from pharmaceutical industry Dr. Rahman joined Pharmacy Discipline of Khulna University as a faculty member.

He earned PhD degree in Medical Science from the University of Tokushima, Japan in 2009 with prestigious Monbukagakusho scholarship. His doctoral research entitled ‘Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation’ was published in the British Journal of Cancer. He was also awarded Tokyo Biochemical Research Foundation (TBRF) fellowship to conduct two-year postdoctoral research in the Department of Cell Biology, Research Institute for Microbial Diseases of Osaka University, Japan. Dr. Rahman then came back to Bangladesh and joined Khulna University to serve the country. His research area was micro RNA mediated deregulation of oncogenes in cancer. His current research interests lie in the area of Molecular genetics of cancer with special focus on genetic polymorphism and cancer susceptibility. Recently he has published his work entitled ‘Genetic polymorphisms in CDH1 and Exo1 genes elevate the prostate cancer risk in Bangladeshi population in Breast Cancer. He received a grant from the Ministry of Science, Information and Technology, Bangladesh in 2015.  Dr. Rahman lives with his partner, a Dental Surgeon, and two school going kids.  Dr. Rahman is member of a number of professional organizations including, Bangladesh Society for Biochemistry and Molecular Biology (BSBMBB), Bangladesh Pharmaceutical Society, American Association of Cancer Research (AACR), Asian federation of Biotechnology (AFOB), Japanese Society for Molecular Biology, The Professional Society for Health Economics and Outcomes Research (ISPOR) etc. Very recently he attended the AACR Annual Meeting 2019 Atlanta in the USA held on March 27- April 3 and presented his research findings.

Bachelor of Pharmacy (Honors)

1994/May

Faculty of Pharmacy, the University of Dhaka, Bangladesh

 

Master of Pharmacy

(Thesis)

1997/February

Faculty of Pharmacy, The University of  Dhaka, Bangladesh

 

Doctor of Philosophy

(PhD in Medical Science.)

2009/March

Department of Human Pathology, Institute of Health Bio Sciences, The University of Tokushima, Japan

Postdoctoral Research

2010/10 to 2012/9

Department of Cell Biology, Research Institute for Microbial Diseases

Osaka University, Japan

# Pharmacogenomics: Association of genetic polymorphism especially single nucleotide polymorphisms (SNPs) with susceptibility, prognosis and treatment option in different types of human cancers

# Epigenetics: Role of miRNA in carcinogenesis and their possibility as therapeutic target

# Pharmacological evaluation of natural products from plant sources

Institute/University

Position

Responsibility

Tenure

 

Armed Forces Medical Institute, Dhaka, Bangladesh

 

Part time Instructor

Teaching

(Diploma in Pharmacy)

1996/6 to 1998/10

Pharmacy Discipline, Khulna University, Bangladesh

 

Lecturer

Research and Teaching

2000/5 to 2001/7

Pharmacy Discipline, Khulna University, Bangladesh

 

Assistant Professor

Research and Teaching

2001/7 to 2004/9

Graduate School of Medicine, The

University of Tokushima, Japan

Research Assistant

 

Research

2006/6  to 2008/12

Pharmacy Discipline, Khulna University, Bangladesh

Associate

Professor

 

Research and Teaching

2004/9 to 2010/02/14

Pharmacy Discipline, Khulna University, Bangladesh

Professor

 

Research and Teaching

2010/02/15 to date





Advanced Chemical Industries (ACI) Ltd, Dhaka, Bangladesh

Product Officer

Training and Product Management

1998/10 to 2000/5

 

 









List of Publication

2020

1.   Hasnain Imtiaz, Amir Hossain, Fahrima Islam, Razia Sultana and Md. Mustafizur Rahman (2020), Bioactivities of Aeschynomene aspera (Fabaceae) Leaf Extract, Bangladesh Pharmaceutical Journal 23(2): 109-116, 2020 (July)

2.    Howlader, N.R., Rahman, M.M., Hossain, M.A., Sultana, R., Hossain, S.M., Mazid, M.A., Rahman, M.M. (2020) Genetic polymorphisms in DNA repair genes XRCC1 and 3 are associated with increased risk of breast cancer in Bangladeshi population. Breast Cancer Res Treat 182(2):739-750 https://doi.org/10.1007/s10549-020-05738-8

2019

3.       Islam, R., Adib, M., Ahsan, M., Rahman, M. M., & Mazid, M. A. (2019). Cholinesterase and Glycation Inhibition Assay of Several Metabolites Obtained from Plant and Fungi. Dhaka University Journal of Pharmaceutical Sciences, 18(1), 31-38. https://doi.org/10.3329/dujps.v18i1.41424

4.       Imtiaz, H., Afroz, S., Hossain, M. A., Bellah, S. F., Rahman, M. M., Kadir, M. S., Rahman, M. M. Genetic polymorphisms in CDH1 and Exo1 genes elevate the prostate cancer risk in Bangladeshi population, Tumor Biology. 2019, https://doi.org/10.1177/1010428319830837

5.       Mahaldar K, Hossain A, Islam F, Islam S, Islam MA, Shahriar M, Rahman MM. Antioxidant and hepatoprotective activity of Piper retrofractum against Paracetamol-induced hepatotoxicity in Sprague-Dawley rat, Natural Product Research, 2019 Jan 19:1-7, DOI: 10.1080/14786419.2018.1550768 (Short communication)

2018

6.      M.N.H. Zilani, M.G. Sarower, A. Hossain, A. Hossain, M.M. Rahman, S.J. Uddin, M.G. Hossain, Polymorphisms in cell cycle regulator gene P27KIP1 and P16INK4A and lung cancer risk in a Bangladeshi population. Pharmacologyonline, 2018, 2:149-160

7.   Ajijul Hakim Alif, Amir Hossain, Md. Akbar Hossain, Tabitha Mitali Madhu, Salma Akter Sumi and Md. Mustafizur Rahman*. Phytochemical and Pharmacological Evaluation of Cyperus odoratus Extract, Bangladesh Pharmaceutical Journal 2018. 21(2): 150-159, 2018 (July)   DOI:10.3329/bpj.v21i2.37927

2017

8.     Hasan M.M., Hossain A., Shamim A., Rahman M.M.* Phytochemical and pharmacological evaluation of ethanolic extract of Lepisanthes rubiginosa L. leaves, BMC Complementary and Alternative Medicine. BMC Complementary and Alternative Medicine (2017) 17:496 [DOI 10.1186/s12906-017-2010-y]

9.  Hossain, A., Murshid, G.M.M., Zilani, M.N.H., Islam F., Sultana R., Hossain M.G., Rahman M.M. TP53 codon72 polymorphism and breast cancer risk in Bangladeshi population.  Breast Cancer, 2017, 24(4), 571-578, doi:10.1007/s12282-016-0740-1

2016

10.  Sumi, S. A., Siraj, M. A.,Hossain, A., Mia,M. S., Afrin, S., Rahman, M. M., Investigation of the Key Pharmacological Activities of Ficusracemosa and Analysis of Its Major Bioactive Polyphenols by HPLC-DAD.Evidence-Based Complementary and Alternative Medicine, 2016, vol. 2016, Article ID 3874516, 9 pages, doi:10.1155/2016/3874516

11.    Hossain, A., Islam, F., Saifuzzaman, M., Saeed M.A.S., Islam, M.K., Murshid, G.M.M., and Rahman M.M. "Bioactivity of Boehmeria Macrophylla (Urticaceae) leaf extract. Orient Pharm Exp Med, 2016,16(3): 233-241. doi:10.1007/s13596-016-0230-1

12.    Mahaldar K., Saifuzzaman M., Irina T., Barman A.K, Islam A.K., Rahman M.M., Islam M.A. Analgesic, anthelmintic and toxicity studies of Solanum violaceum Linn. Leaves. Orient Pharm Exp Med, 2016, 16(2): 147-152 doi: 10.1007/s13596-016-0227-9

13.    Zilani, M.N.H., Islam, M.A., Khushi, S.S.,Shilpi J.A. Rahman M.M., Hossain, M.G., Analgesic and antioxidant activities of Colocasi afallax, Orient Pharm Exp Med, 2016, 16(2):131–137 DOI:10.1007/s13596-016-0222-1

2015

14.    Islam F, Hossain A, Hossain MG, Murshid GMM, Rahman MM. Evaluation of Antioxidant, Analgesic and Cytotoxic Activities of T. angustata L. (Family– Typhaceae) Root. Dhaka Univ. J. Pharm. Sci. 2015 (June); 14(1): 53-59. https://doi.org/10.3329/dujps.v14i1.23736

15.    Khan MA, Islam MK, Siraj MA, Saha S, Barman AK, Awang K, Rahman MM, Shilpi JA, Jahan R, Islam E and Rahmatullah M, Ethnomedicinal survey of various communities residing in Garo Hills of Durgapur, Bangladesh. J EthnobiolEthnomed. 2015 May 30; 11(1): 44 (Epub ahead of print). DOI: 10.1186/s13002-015-0033-3

16.    Islam MK, Siraj MA, Sarker AB, Saha S, Mahmud I, Rahman MM. In-vitro anthelmintic activity of three Bangladeshi plants against Paramphistomumcervi and Haemonchuscontortus, Journal of Complementary & Integrative Medicine, 2015, 12(2):171-174, DOI: 10.1515/jcim-2014-0059.

17.    SmFaysalBellah, Md. IqubalHossainRaju, SM SakerBillah,ShaikhEmdadurRahman, G.M.M. Murshid, Md. Mustafizur Rahman, Evaluation of antibacterial and antidiarrhoeal activity of ethanolic extract of Feronialimonia Leaves. The Pharma Innovation Journal 2015; 3(11): 50-54.

2014

18.    Murshid GMM, Barman AK and Rahman MM, Evaluation of antioxidant, analgesic and cytotoxic activities of the aerial part of Cassia sophera L. (Caesalpiniaceae). International Journal of Phytopharmacology 2014; 5(5): 383-389.

19.    Sharmin Islam, Md. HasibulAlam, Md. Mustafizur Rahman, Shaikh Jamal Uddin, Sm Faysal Bellah, Gazi Md. Manjur Murshid. Anthelmintic and cytotoxic activity of the ethanolic extract of Phoenix sylvestris root. World J Pharm Sci 2014; 2(8):725-728

20.    Imran Mahmud, Md. Khirul Islam, SanjibSaha, Apurba Kumar Barman, Md. Mustafizur Rahman, Md. Anisuzzman, Taufiq Rahman, Abdullah Al-Nahain, Rownak Jahan and Mohammed Rahmatullah. Pharmacological and Ethnomedicinal overview of Heritierafomes: future prospects. International Scholarly Research Notices, Volume 2014, Article ID 938543, 12 pages, http://dx.doi.org/10.1155/2014/938543

21.    Md. Khirul Islam, Sanjib Saha, Imran Mahmud, KhalitMohamad, KhalijahAwang, Shaikh Jamal Uddin, Md. Mustafizur Rahman, Jamil A Shilpi. An ethnobotanical study of medicinal plants used by tribal and native people of Madhupur Forest Area, Bangladesh. Journal of Ethnopharmacology. 2014,151:921-30

2013

22.    Md. Saifuzzaman, Md. AwladHossain, Md. Anwar Hossain, Md. Amirul Islam, Gazi Md. MonjurMurshid and Md. Mustafizur Rahman, Cytotoxic and antibacterial activities of ethanolic extract of Leeaindica leaves. HamdardMedicus. 2013; 56(2): 12-19

23.    Mohammad Abdul MotalibMomin, SmFaysalBellah, MizanurRahaman Khan, Md. IqubalHossainRaju, Md. MustafizurRahman and AnjumanAra Begum. Phytopharmacological evaluation of ethanolic extract of Feronialimonia leaves. Am. J. Sci. Ind. Res., 2013, 4(5): 468-472 doi:10.5251/ajsir.2013.4.5.468.472

24.    M. M. Rahman, R. Sultana, M. R. Khan, M. A. Islam. Binding of Triprolidine Hydrochloride to Bovine Serum Albumin: Estimation of Binding parameters & Characterization of Binding Sites. Turk J Pharm Sci, 2013, 10(1), 49-56

       http://cms.galenos.com.tr/Uploads/Article_12404/49-56.pdf 

2012

25.    M A. ISLAM, M. Saifuzzaman, F. Ahmed, M. M. Rahman, N. A. Sultana, K. Naher. Antinoceptive activity of methanolic extract of Acanthus Ilicifolius Linn. Leaves. 2012, Turk J Pharm Sci, 9(1): 51-60

26.    M. S. Islam Howlader, Md. MofizurRahman,Abul Bashar Ripon Khalipha, Firoj Ahmed and Md. Mustafizur Rahman. Antioxidant and antidiarrhoeal potentiality of Diospyrosblancoi. International Journal of Pharmacology, 2012, 8(5) :403-409

        DOI: 10.3923/ijp.2012.403.409 URL: https://scialert.net/abstract/?doi=ijp.2012.403.409

2010

27.    M.A. Islam, S. Parvin, M. M. Rahman, M.I. Ahmed, N.N. Biswas, U.K. Karmakar and K. Naher. Phytochemical and biological investigation of seeds of Hyptissuaveolens. 2010, Khulna University Studies, 10 (1&2): 185-190

28.    Rahman MM, Qian ZR, Wang EL, Yoshimoto K, Nakasono M, Sultana R, Yoshida T, Hayashi T, Haba R, Ishida M, Okabe H, Sano T. DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.HumPathol. 2010 Aug; 41(8):1069-78. PMID: 20381114 DOI: 10.1016/j.humpath.2010.01.011

29.    Wang EL, Qian ZR, Rahman MM, Yoshimoto K, Yamada S, Kudo E, Sano T.Increased expression of HMGA1 correlates with tumour invasiveness and proliferation in human pituitary adenomas. Histopathology, 2010 March ; 56(4):501-9 DOI: 10.1111/j.1365-2559.2010.03495.x

2009

30.    Wang EL, Qian ZR, Yamada S, Rahman MM, Inosita N, Kageji T, Endo H, Kudo E, Sano T. Clinicopathological characterization of TSH-producing adenomas: special reference to TSH-immunoreactive but clinically non-functioning adenomas. Endocr Pathol. 2009; 20(4):209-20. DOI: 10.1007/s12022-009-9094-y

31.    Rahman MM, Qian ZR, Wang EL, Sultana R, Kudo E, Nakasono M, Hayashi T, Kakiuchi S, Sano T.  Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation. British Journal of Cancer, 2009 Feb 10;100(3):501-10. DOI: 10.1038/sj.bjc.6604883

32.    Qian ZR, Asa SL, Siomi H, Siomi MC, Yoshimoto K, Yamada S, Wang EL, Rahman MM, Inoue H, Itakura M, Kudo E, Sano T. Overexpression of HMGA2 relates to reduction of let-7 and its relationship to clinicopathological features in pituitary adenomas. Modern Pathology, 2009; 22(3):431-41 DOI: 10.1038/modpathol.2008.202

2008

33.    Abdul Kader Obari, Toshiaki Sano, KenitichiOyama, EijiKudo, Zhi R Qian, Akiko Yoneda, NasimRayhan, MustafizurRahman M, Shozo Yamada. 2008. Clinicopathological features of growth hormone-producing pituitary adenomas: Difference among various types defined by cytokeratin distribution pattern including a transitional form. Endocrine Pathology, 19(2): 82-91 DOI: 10.1007/s12022-008-9029-z

2006

34.    Shuhei Tomita, Shin-IchiMaekawa, MustafizurRahman, Fumi Saito, Ryoichi Kizu, Keiko Tohi, Tomoo Ueno, Hiroshi Nakase, Frank J. Gonzalez, Kazuichi Hayakawa, Takashi Korenaga and YousukeTakahama. 2006. Thymic involution produced by diesel exhaust particles and their components in mice. Toxicological & Environmental Chemistry, 88(1): 113–124 https://doi.org/10.1080/02772240500475128

2005

35.    M. M. Rahman, M. H. Rahman and N.N. Rahman. Competitive Binding of Ibuprofen and Naproxen to Bovine Serum Albumin: Modified form of Drug–Drug Displacement Interaction at the Binding Site.2005, Pakistan J Pharmaceut. Sci, 18(1):43-7 PMID:16431382

2004 

36.    S. M. Mahbub Alam, M. M. Rahman, M. H. Rahman and N. N Rahman. Tetracycline hydrochloride binds with high affinity to warfarin site (site-I) on bovine serum albumin: temperature and pH influence this binding process. 2004, Pakistan Journal of Biological Sciences, 7 (12): 2099-2104 DOI: 10.3923/pjbs.2004.2099.2104 URL: https://scialert.net/abstract/?doi=pjbs.2004.2099.2104

2003

37.    Firoj Ahmed, Prabir K. Das, M. Amirul Islam, K.M. Rahman, M.M. Rahman and M.S.T. Selim. Antibacterial activity of Cordyline terminalis Kunth. Leaves. 2003, J. Med. Sci., 3 (5-6) : 418-422 DOI: 10.3923/jms.2003.418.422  URL: https://scialert.net/abstract/?doi=jms.2003.418.422

38.    M. M. Rahman, M. H. Rahman and N. N. Rahman. Protein binding aspects of ibuprofen and naproxen to bovine serum albumin. 2003, Dhaka University Journal of Pharmaceutical Sciences, 2(1): 43-47

2002

39.    A. B. S. M. Osman Gani, M.K. Hossain, M. M. Rahman and M. H. Rahman. Binding of dexamethasone phosphate to bovine serum albumin: effect of temperature and pH. 2002. Bangladesh Pharmaceutical Journal, Bangladesh Pharmaceutical Society, 12(1): 31-35

40.    A. B. S. M. Osman Gani, M.K. Hossain, M. M. Rahman and M. H. Rahman, Binding of testosterone phenyl propionate to bovine serum albumin: effect of temperature and pH. 2002. Saudi Pharmaceutical Journal, 10(3): 92-97

2001

41.    M. M. Rahman, A.B.S.M. Osman Gani, M.A. Choudhury and M.H. Rahman. Binding of dexamethasone phosphate and testosterone phenyl propionate to bovine serum albumin: drug–drug interaction at the binding site. 2001. Pakistan Journal of Biological Sciences, 4(5): 572-574 DOI: 10.3923/pjbs.2001.572.574 URL: https://scialert.net/abstract/?doi=pjbs.2001.572.574

42.    M. M. Rahman, M. Rashed Khan, M. H. Rahman, Binding of estriol to bovine serum albumin: Determination of binding parameters and characterization of binding sites. 2001, Khulna University Studies, Bangladesh 3(2): 545-548

 

Conference papers

1.       Md. Mustafizur Rahman, Nupur Rani Hawlader, Md. Mostafizur Rahman, Md. Amir Hossain. Genetic polymorphisms in DNA repair genes XRCC1 and 3 are associated with increased risk of breast cancer in Bangladeshi population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1617. DOI: 10.1158/1538-7445.AM2019-1617 (https://cancerres.aacrjournals.org/content/79/13_Supplement/1617)

 

2.       Mustafizur Rahman, Razia Sultana, Ryo Iwamoto, Eisuke Mekada. Micro-RNA mediated deregulation of hHB-EGF in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4424. DOI:10.1158/1538-7445.AM2018-4424 (https://cancerres.aacrjournals.org/content/78/13_Supplement/4424)

 

3.  Hasnain Imtiaz, Sharmin Afroz, Md. Amir Hossain, Sm Faysal Bellah, Md. Mustafizur Rahman. The study of single-nucleotide polymorphisms (SNPs) of tumor suppressor gene in prostate cancer patient of Bangladeshi population [abstract]. In: Proceedings of the AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; 2017 Dec 2-5; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(16 Suppl):Abstract nr A094. DOI: 10.1158/1538-7445.PRCA2017-A094

(https://cancerres.aacrjournals.org/content/78/16_Supplement/A094)

Book Chapter

1.       Rahman, M. M. (2019) ফার্মাসিউটিক্যাল রেগুলেটরী স্ট্যান্ডার্ডস (জিএমপি, আইএসও, আইসিএইচ, ভ্যালিডেশন এবং টিকিউএম) In ড। মো। শাহ এমরান (Eds.) ফার্মেসী স্বাস্থ্যসেবা (pp. 130-140) শোভা প্রকাশ, ঢাকা

2.       Sano T, Qian Z.R, Rahman M. M.,Yamada S. 2006. Histopathological differentiation of functional pituitary adenoma, The Medical Frontline: The ABC of New Diagnosis and Therapy-43 Endocrine 3 Functional Endocrine Tumor p22-29

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